| Achievements | Unlock |
| Dead Presidents (10) | Completed 'When good heists...' but not caught... |
| Jumped In (10) | Created and Shared a Character online |
| The Welcome Wagon (15) | Completed 'I'm Free-Free Falling!' landed safely in Steelport with a 9.0 from the Belgians |
| Ow My Balls (10) | Did your first nutshot and testicle assault, sack tapping is bad news kids! |
| Opulence, You Has It (20) | Completed 'Party Time' and got the saints their first crib in Steelport |
| A Better Person (15) | Bought your first upgrade, now you have action Kung Fu Grip! |
| We're Takin' Over (20) | Completed Pierce's city takeover intro missions |
| Kuh, Boom (20) | Completed Act 1, killed Phillipe Loren, and destroyed 'The Tower' |
| Bo-Duke-En! (10) | 50 Quick Vehicle hijacks, the Dukes would be proud |
| Gellin' Like Magellan (20) | Explored every hood in Steelport, you've been around the world |
| Shake and Bake (10) | Completed your first challenge, it was a challenge right? |
| Go into the Light (20) | Completed all instances of Guardian Angel |
| Haters Gonna Hate (15) | Killed 1000 Gang Members |
| Gotta Break 'Em In (25) | Completed 'The Ho Boat' and decided the Ho's fate, do you feel proud of yourself? |
| Kill-deckers.exe (25) | Completed ' 01100010011011110110111101100010 |
| I Heart Nyte Blade (25) | Completed 'STAG Party' and decide Josh Birk's fate, we hope you chose wisely |
| Titanic Effort (40) | Completed Act 2 and destroyed the Thermopylae, but the fight is not over yet |
| Once Bitten.... Braaaaaaains! (25) | Completed 'Zombie Attack!' Did anyone say Braaaaaaains? |
| Murderbrawl 31 (25) | Completed 'Murder Brawl XXXI', the mask of Killbane, what did you do? |
| Gangstas... In Space (30) | Completed Act 3 in another way, General Killbane is dead |
| Getting the Goods (10) | 25% of Collectibles found. Drugs, Sex, Cash, and Celebrity... what else is there? |
| And Boom Goes the Dynamite! (20) | Completed instance of Heli Assault |
| Hanging With Mr. Pierce (25) | Took Control of the entire downtown district for the Saints. |
| The American Dream (10) | Customize 10 Vehicles |
| Stay Classy Steelport (10) | Kill 25 gang members each with 'the penetrator' AND the fart in a jar |
| Third and 30 (40) | Spend over 30 hours in Steelport |
| Flash the Pan (10) | Destroy all gang operations in Steelport |
| Pimped Out Pad (10) | Upgrade one stronghold to its full glory |
| Cowboy Up (10) | Fully Upgrade one weapon in each slot |
| Who Loves Ya Baby (10) | Kill 50 Brutes |
| Love/Hate Relationship (10) | Taunt AND/OR compliment 50 gang members |
| Gender Equality (10) | Play for at least 2 hours as a male character and 2 hours as a female character |
| You're My Hero (30) | Complete all challenges |
| Life of the Party (20) | Find 100% of all collectibles |
| Hi-Jack It (10) | Steal and deliver all vehicle theft targets |
| Everything is Permitted (10) | Kill all of the hitman assassination targets |
| Have A Reality Climax (20) | Complete all instances of Professor Genki's Super Ethical Reality Climax |
| Tank You Very Much (20) | Complete all instances of Tank Mayhem |
| Porkchop Sandwiches (20) | Complete all instances of Trail Blazing |
| Double Dose of Pimping (20) | Complete all instances of Snatch |
| Your Backseat Smells Funny (20) | Complete all instances of Escort |
| Fence Killa 2011 (20) | Complete all instances of Mayhem |
| Tune In, Drop Off (20) | Complete all instances of Trafficking |
| Ouch. (20) | Complete all instances of Insurance Fraud |
| Bright Lights, Big City (80) | Complete all city takeover gameplay in the entire city of Steelport |
| You're the Best... (25) | Complete all city takeover gameplay in the Carver Island District |
| Hack the Planet (25) | Complete all city takeover gameplay in the Stanfield District |
| Mourning Stars (25) | Complete all city takeover gameplay in the New Colvin District |
| Mr. Fury Would Be Proud (30) | Complete Act 3 in one way |
| Tower Defense (20) | Complete Act 1 in one way |
